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KMID : 0545120160260030483
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 3 p.483 ~ p.487
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Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia
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Choi Il-Dong
Kim Sung-Hwan
Jeong Ji-Woong
Lee Dong-Eun
Huh Chul-Sung
Hong Seong-Soo
Sim Jae-Hun
Ahn Young-Tae
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Abstract
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The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 × 109 CFU/day of L. plantarum KY1032 and 5 × 109 CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR.
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KEYWORD
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Triglyceride, probiotics, Lactobacillus plantarum, Lactobacillus curvatus, apolipoprotein A-V
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